Vinylic Trifluoromethylselenolation via Pd-Catalyzed C−H Activation
A. de Zordo-Banliat, K. Grollier, J. Vigier, E. Jeanneau, G. Dagousset, B. Pegot, E. Magnier, Th. Billard
Chem. Eur. J. 2022, 28, e202202299


Electrochemical Trifluoromethylselenolation of Activated Alkyl Halides
K. Grollier, C. Ghiazza, A. Tlili, T. Billard, M. Médebielle, J. C. Vantourout
Eur. J. Org. Chem. 2022, e202200123.


Study of Carbamoyl Fluoride: Synthesis, Properties and Applications
C. Bonnefoy, E. Chefdeville, C. Tourvieille, A. Panossian, G. Hanquet, F. Leroux, F. Toulgoat, T. Billard
Chem. Eur. J. 2022, 28, e202201589.


O. Piva
Five-Membered Rings With Three Oxygen or Sulfur Atoms in 1,2,3-Positions.
In: Comprehensive Heterocyclic Chemistry IV. vol. 6, pp. 120-145.
D. S. Black, J. Cossy, C.V. Stevens
Oxford: Elsevier.


Synthesis, Reactivity and Activation Modes of Fluoroalkyl Thiosulfonates and Selenosulfonates
C. Ghiazza, T. Billard
Eur. J. Org. Chem. 2021, 2021, 5571-5584. (link)


Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4-Dinitro-Trifluoromethoxybenzene
C. Bonnefoy, E. Chefdeville, A. Panossian, G. Hanquet, F. R. Leroux, F. Toulgoat, T. Billard
Chem. Eur. J. 2021, 27, 15986-15991 (link)


Photoredox-catalyzed hydroxymethylation of β-ketoesters: application to the synthesis of [3.3.3] propellane lactones
Y. Nassar; O. Piva Organic & Biomolecular Chemistry (2021), 19(42), 9251-9259. (link)


Fe-mediated nucleophilic trifluoromethylselenolation of activated alkyl bromides via umpolung reactivity of trifluoromethyl tolueneselenosulfinate
K. Grollier, E. Chefdeville, A. De Zordo-Banliat, B. Pegot, G. Dagousset, E. Magnier, T. Billard
Tetrahedron 2021, 100, 132498. (link)


Solvent free nucleophilic selenocyanation with [bmim][SeCN]. Direct access to perfluoroalkylselenide compounds
A. De-Zordo Banliat, K. Grollier, A. Damond, T. Billard, G. Dagousset, E. Magnier, B. Pégot
Tetrahedron 2021, 101, 132507. (link)


Recent synthetic methods towards the –OCHF2 moiety
A. Loison, F. Toulgoat, T. Billard, G. Hanquet, A. Panossian, F. R. Leroux
Tetrahedron 2021, 99, 132458. (link)

Aromatic Trifluoromethylselenolation via Pd-catalyzed C−H functionalization
K. Grollier, E. Chefdeville, E. Jeanneau, T. Billard
Chem. Eur. J. 2021, 27, 12910-12916. (link)


Reactions of organic peroxy radicals, RO2, with substituted and biogenic alkenes at room temperature: unsuspected sinks for some RO2 in the atmosphere?
Barbara Nozière and Fabienne Fache
Chem. Sci., 2021, 12, 11676 (link)


Caryatin and 3’-O-methylcaryatin contents in edible yams (Dioscorea spp.)
Benjamin Fel, Anne Baudouin, Fabienne Fache, Sonia Czarnes, Vincent Lebot, Laurent Legendre
Journal of Food Composition and Analysis 102 (2021) 104010 (link)


Different Alterations of Agonist and Antagonist Binding to 5-HT 1A Receptor in a Rat Model of Parkinson’s Disease and Levodopa-Induced Dyskinesia: A MicroPET Study
B. Vidal, E. Levigoureux, S. Chaib, C. Bouillot, T. Billard, A. Newman-Tancredi, L. Zimmer
J. Parkinsons Dis. 2021, 11, 1257-1269. (link)


Trifluoromethylselenyl)methylchalcogenyl as Emerging Fluorinated Groups: Synthesis under Photoredox Catalysis and Determination of the Lipophilicity
K. Grollier, A. De Zordo-Banliat, F. Bourdreux, B. Pegot, G. Dagousset, E. Magnier, T. Billard
Chem. Eur. J. 2021, 27, 6028-6033. (link)


[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations
M. Colom, B. Vidal, S. Fieux, J. Redoute, N. Costes, F. Lavenne, I. Mérida, Z. Irace, T. Iecker, C. Bouillot, T. Billard, A. Newman-Tancredi, L. Zimmer
Front. Neurosci. 2021, 15, doi:10.3389/fnins.2021.622423.


Design, Synthesis, and Evaluation of α-(Hydroxymethyl)cycloalkanols
Y. Nassar; O. Piva
European Journal of Organic Chemistry (2021), 2021(7), 1037-1054. (link)


A short route to access oxaspiro[n,3,3]propellanes
Y. Nassar, O. Piva, Org. Bio. Chem. 2020, 18, 5811-5815 (link)


Metal-free nucleophilic trifluoromethylselenolation via an iodide-mediated umpolung reactivity of trifluoromethylselenotoluenesulfonate
K. Grollier, A. Taponard, A. De Zordo-Banliat, E. Magnier, T. Billard
Beilstein J. Org. Chem. 2020, 16, 3032-3037 (Special issue, on invitation). (link)


When Fluorine Meets Selenium
T. Billard, F. Toulgoat
in Emerging Fluorinated Motifs. (Eds.: D. Cahard, J. A. Ma), Wiley‐VCH Verlag, Weinheim, Germany, 2020, Vol.2, pp. 691-721. (link)


Metal-free nucleophilic trifluoromethylselenolation via an iodide-mediated umpolung reactivity of trifluoromethylselenotoluenesulfonate
K. Grollier, A. Taponard, A. De Zordo-Banliat, E. Magnier, T. Billard
Beilstein J. Org. Chem. 2020, 16, 3032-3037 (Special issue, on invitation). (link)


Synthetic Approaches to Fluoroalkyltelluryl-Substituted Compounds
K. Grollier, A. Taponard, T. Billard
Eur. J. Org. Chem. 2020, 6943-6954. (link)


Environmentally Compatible Access to α-Trifluoromethylseleno-Enones
K. Grollier, A. Taponard, C. Ghiazza, E. Magnier, T. Billard
Helv. Chim. Acta 2020, 103, e2000185 (Special issue dedicated to Antonio Togni ; on invitation). (link)


Change in Expression of 5-HT 6 Receptor at Different Stages of Alzheimer’s Disease: A Postmortem Study with the PET Radiopharmaceutical [ 18F]2FNQ1P
P. Courault, S. Emery, S. Bouvard, F. Liger, F. Chauveau, D. Meyronet, A. Fourier, T. Billard, L. Zimmer, S. Lancelot
J. Alzheimer's Dis. 2020, 75, 1329-1338. (link)


Formal Enantioselective Synthesis of Nhatrangin A,
S. Feuillastre, L. Raffier, B. Pelotier, O. Piva,
Org. & Biomol. Chem. DOI: 10.1039/C9OB02639H


Preclinical validation of [18F]2FNQ1P as a specific PET radiotracer of 5-HT6 receptors in rat, pig, non-human primate and human brain tissue S. Emery, S. Fieux, B. Vidal, P. Courault, S. Bouvard, C. Tourvieille, T. Iecker, T. Billard, L. Zimmer, S. Lancelot Nucl. Med. Biol. 2020, 82-83, 57-63. (link)


18F-F13640 PET imaging of functional receptors in humans
M. Colom, N. Costes, J. Redouté, F. Dailler, F. Gobert, D. Le Bars, T. Billard, A. Newman-Tancredi, L. Zimmer
Eur. J. Nucl. Med. Mol. Imag. 2020, 47, 220-221. (link)


Green access to α-haloalkyl and α-halobenzyl esters, versatile intermediates for the one-pot two step synthesis of O,O’-diacyl acetals using zinc-based ionic liquid catalyst.
F. Fache, I. de Azpiazu, B. Pelotier, O. Piva, C. Gozzi, Synthesis 2019, 51, 2430-2434.

Access to polyfluorinated tetrahydropranyl amides via Prins-Ritter cyclization under green conditions.
C. Segovia, F. Fache, B. Pelotier, O. Piva, ChemistrySelect 2019, 4, 3191-3194.


Difluoro(aryl)(perfluoroalkyl)-λ4-sulfanes and Selanes: Missing Links of Trichloroisocyanuric Acid/Potassium Fluoride Chemistry
F. Brüning, C. R. Pitts, J. Kalim, D. Bornemann, C. Ghiazza, J. de Montmollin, N. Trapp, T. Billard, A. Togni
Angew. Chem. Int. Ed. 2019, 58, 18937-18941. (link)


11C-Labeling: Intracyclic Incorporation of Carbon-11 into Heterocycles
F. Liger, F. Cadarossanesaib, T. Iecker, C. Tourvieille, D. Le Bars, T. Billard
Eur. J. Org. Chem. 2019, 6968-6972. (link)


Chalcogen OCF3 Isosteres Modulate Drug Properties without Introducing Inherent Liabilities
C. Ghiazza, T. Billard, C. Dickson, A. Tlili, C. M. Gampe
ChemMedChem 2019, 14, 1586-1589. (link)


Visible-Light-Mediated Synthesis of Trifluoromethylthiolated Arenes
C. Ghiazza, C. Monnereau, L. Khrouz, T. Billard, A. Tlili
Synthesis 2019, 51, 2865-2870. (link)


Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!
M. Zhang, G. Hugon, C. Bouillot, R. Bolbos, J.-B. Langlois, T. Billard, F. Bonnefoi, B. Li, L. Zimmer, F. Chauveau
Contrast Media Mol. Imaging 2019, Article ID 9294586, doi:10.1155/2019/9294586. (link)


Umpolung Reactivity of Fluoroalkylselenotoluenesulfonates: Towards a Versatile Reagent
C. Ghiazza, A. Kataria, A. Tlili, F. Toulgoat, T. Billard
Asian J. Org. Chem. 2019, 8, 675-678 (Special Issue: Organofluorine Chemistry ; on invitation). (link)


Merging Visible-Light Catalysis for the Direct Late-Stage Group-16–Trifluoromethyl Bond Formation
C. Ghiazza, T. Billard, A. Tlili
Chem. Eur. J. 2019, 25, 6482-6495. (link)

New Avenues in Radical Trifluoromethylselenylation with Trifluoromethyl Tolueneselenosulfonate
C. Ghiazza, C. Monnereau, L. Khrouz, M. Médebielle, T. Billard, A. Tlili
Synlett 2019, 30, 777-782. (link)


Evaluation of [18F]2FP3 in pigs and non-human primates
H. D. Hansen, C. C. Constantinescu, O. Barret, M. M. Herth, J. H. Magnussen, S. Lehel, A. Dyssegaard, J. Colomb, T. Billard, L. Zimmer, G. Tamagnan, G. M. Knudsen
J. Labelled Compd. Radiopharm. 2019, 62, 34-42. (link)


Regioselective remote CH fluoroalkylselenolation of 8-aminoquinolines
C. Ghiazza, M. Ndiaye, A. Hamdi, A. Tlili, T. Billard
Tetrahedron  2018, 74, 6521-6526. (link)


Serotonin receptor imaging by 18F-PET.
T. Billard, F. Liger, M. Verdurand
in Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals. (Eds.: G. Haufe, F. Leroux), Elsevier Science, London, United Kingdom, 2018, pp. 459-518.


Merging metathesis and photochemical Csp3-H activation: Access to masked β-formyl hexanolides and their rearrangement to furofuranones
Quentin Glenadel, Youssef Nassar, Ludovic Raffier, Sebastiaan Veys, Olivier Piva
Tetrahedron 2018, 74, 5367-5373. (link)


Visible-light promoted fluoroalkylselenolation: toward the reactivity of unsaturated compounds
C. Ghiazza, L. Khrouz, C. Monnereau, T. Billard, A. Tlili
Chem. Commun. 2018, 54, 9909-9912. (link)


Visible-Light-Mediated Metal-Free Synthesis of Trifluoromethylselenolated Arenes
C. Ghiazza, V. Debrauwer, C. Monnereau, L. Khrouz, M. Médebielle, T. Billard, A. Tlili
Angew. Chem. Int. Ed. 2018, 57, 11781-11785. (link)


In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging
M. Verdurand, E. Levigoureux, W. Zeinyeh, L. Berthier, M. Mendjel-Herda, F. Cadarossanesaib, C. Bouillot, T. Iecker, R. Terreux, S. Lancelot, F. Chauveau, T. Billard, L. Zimmer
Mol. Pharm. 2018, 15, 3153-3166. (link)


Direct α-C–H Trifluoromethylselenolation of Carbonyl Compounds
G. Clément, T. Anis, B. Thierry
Eur. J. Org. Chem. 2018, 3680-3683. (link)


18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging
B. Vidal, S. Fieux, M. Colom, T. Billard, C. Bouillot, O. Barret, C. Constantinescu, G. Tamagnan, A. Newman-Tancredi, L. Zimmer
Brain Struct. Funct. 2018, 223, 2973-2988. (link)


Nucleophilic trifluoromethylthiolation of organoselenocyanates with trifluoromethanesulfenamide reagent: Access to CF3SSe-containing compounds
Q. Glenadel, C. Ayad, M.-A. D’Elia, T. Billard, F. Toulgoat
J. Fluorine Chem. 2018, 210, 112-116. (link)


Synthetic Approaches to Trifluoromethylselenolated Compounds
A. Tlili, E. Ismalaj, Q. Glenadel, C. Ghiazza, T. Billard
Chem. Eur. J. 2018, 24, 3659-3670. (link)


Amyloid-Beta Radiotracer [18F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue
M. Verdurand, E. Levigoureux, S. Lancelot, W. Zeinyeh, T. Billard, I. Quadrio, A. Perret-Liaudet, L. Zimmer, F. Chauveau
Contrast Media & Molecular Imaging 2018, Article ID 9165458, doi:10.1155/2018/9165458. (link)


Fluorous l-Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity
A. Granados, A. d. Olmo, F. Peccati, T. Billard, M. Sodupe, A. Vallribera
J. Org. Chem. 2018, 83, 303-313. (link)


A Metal-Free Route to Heterocyclic Trifluoromethyl- and Fluoroalkylselenolated Molecules
Q. Glenadel, E. Ismalaj, T. Billard
Org. Lett. 2018, 20, 56-59. (link)


Exploring the Reactivity of Trifluoromethyl Tolueneselenosulfonate with Alkynes under Copper Catalysis
C. Ghiazza, V. Debrauwer, T. Billard, A. Tlili
Chem. Eur. J. 2018, 24, 97-100. (link)


Electrophilic trifluoromethylselenolation of terminal alkynes with Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate
C. Ghiazza, A. Tlili, T. Billard
Beilstein J. Org. Chem. 2017, 13, 2626-2630 (Special issue, on invitation). (link)


An easier and quicker access to (benzenesulfonyl)difluoromethanesulfenamide reagent
E. Ismalaj, T. Billard
J. Fluorine Chem. 2017, 203, 215-217 (Special issue, on invitation) (link)


Desymmetrization of hepta-1,6-dien-4-ol by a highly stereoselective tandem Prins-Ritter cyclization: Access to new THP acetamides
T. Glachet, F. Fache, B. Pelotier, O. Piva
Synthesis 2017, 49, 5197-5202 (link)


[11C]PF-3274167 as a PET radiotracer of oxytocin receptors: Radiosynthesis and evaluation in rat brain
B. Vidal, I. A. Karpenko, F. Liger, S. Fieux, C. Bouillot, T. Billard, M. Hibert, L. Zimmer
Nucl. Med. Biol. 2017, 55, 1-6. (link)


Copper-Catalyzed Direct Trifluoro- and Perfluoroalkylselenolations of Boronic Acids with a Shelf-Stable Family of Reagents
Q. Glenadel, C. Ghiazza, A. Tlili, T. Billard
Adv. Synth. Catal. 2017, 359, 3414-3420. (link)


Fluor et Santé (Fluorine and health)
T. Billard, E. Magnier
Actualité Chimique 2017, 421, 31-34 (link)


Trifluoromethyl- and Fluoroalkylselenolations of Alkynyl Copper(I) Compounds
C. Ghiazza, T. Billard, A. Tlili
Chem. Eur. J. 2017, 23, 10013-10016. (link)


Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors
V. Sgambato-Faure, T. Billard, E. Météreau, S. Duperrier, S. Fieux, N. Costes, L. Tremblay, L. Zimmer
Front. Pharmacol. 2017, 8, doi:10.3389/fphar.2017.00471. (link)


Trifluoromethylselenolation and Fluoroalkylselenolation of Alkenes by Electrophilic Addition
C. Ghiazza, Q. Glenadel, A. Tlili, T. Billard
Eur. J. Org. Chem. 2017, 2017, 3812-3814. (link)


Electrophilic Trifluoromethylselenolation of Boronic Acids
C. Ghiazza, A. Tlili, T. Billard
Molecules 2017, 22, 833-841. (Special issue, on invitation) (link)


Easy Access to SCF2-Containing Molecules through a Versatile Reagent
E. Ismalaj, Q. Glenadel, T. Billard
Eur. J. Org. Chem. 2017, 1911-1914. (link)


Generation of the SCF3 Radical by Photoredox Catalysis: Intra- and Intermolecular Carbotrifluoromethylthiolation of Alkenes
G. Dagousset, C. Simon, E. Anselmi, B. Tuccio, T. Billard, E. Magnier, Chem. Eur. J. 2017, 23, 4282-4286. (link)


A bioinspired heterogeneous catalyst based on the model of the manganese-dependent dioxygenase for selective oxidation using dioxygen†
Jérémy Chaignon, Marie Gourgues, Lhoussain Khrouz, Nicolas Moliner, Laurent Bonneviot, Fabienne Fache, Isabel Castro and Belen Albela, RSC Advances, 2017, 7, 17336-17345. (link)


Towards CF3S Group: From Trifluoromethylation of Sulfides to Direct Trifluoromethylthiolation.
F. Toulgoat, T. Billard
in Modern Synthesis Processes and Reactivity of Fluorinated Compounds: Progress in Fluorine Science (Eds.: H. Groult, F. Leroux, A. Tressaud), Elsevier Science, London, United Kingdom, 2017, pp. 141-179. (link)


Electrophilic Trifluoromethyl- and Fluoroalkylselenolation of Organometallic Reagents
Q. Glenadel, E. Ismalaj, T. Billard
Eur. J. Org. Chem. 2017, 530-533. (link)


Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines
L. J. C. Bonazaba Milandou, H. Carreyre, S. Alazet, G. Greco, A. Martin-Mingot, C. Nkounkou Loumpangou, J.-M. Ouamba, F. Bouazza, T. Billard, S. Thibaudeau
Angew. Chem. Int. Ed. 201756, 169-172. (link)


Benzyltrifluoromethyl (or Fluoroalkyl) Selenide: Reagent for Electrophilic Trifluoromethyl (or Fluoroalkyl) Selenolation
Q. Glenadel, E. Ismalaj, T. Billard
J. Org. Chem. 2016, 81, 8268-8275.(link)


Synthetic Approaches to Trifluoromethoxy-Substituted Compounds
A. Tlili, F. Toulgoat, T. Billard
Angew. Chem. Int. Ed. 2016, 55, 11726-11735.(link)


Copper-Catalyzed Perfluoroalkylthiolation of Alkynes with Perfluoroalkanesulfenamides
A. Tlili, S. Alazet, Q. Glenadel, T. Billard 
Chem. Eur. J. 2016, 22, 10230-10234.(link)
Highlighted on the ChemistryViews website


Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer’s disease: A post-mortem study with PET radiopharmaceuticals
B. Vidal, J. Sebti, M. Verdurand, S. Fieux, T. Billard, N. Streichenberger, C. Troakes, A. Newman-Tancredi, L. Zimmer
Neuropharmacology 2016, 109, 88-95.(link)


Metal-Free Direct Dehydroxytri­fluoromethylthiolation of Alcohols via the Umpolung Reactivity of Trifluoromethanesulfenamides
Q. Glenadel, A. Tlili, T. Billard
Eur. J. Org. Chem. 2016, 1955-1957.(link)


Direct Perfluoroalkylthiolation of Few Chalcogenols
Q. Glenadel, T. Billard
Chin. J. Chem . 2016, 34, 455-458 (Special issue, on invitation). (link)


Multigram Scale Syntheses of First and Second Generation of Trifluoromethanesulfenamide Reagents
Q. Glenadel, S. Alazet, F. Baert, T. Billard
Org. Process Res. Dev. 2016, 20, 960-964.(link)


Trifluoromethanesulfenamides: new reagents for direct S-CF3 bond formation
T. Billard
Chim. Oggi - Chem. Today 2016, 34, 18-21 (on invitation). (link)


Copper-Catalyzed Trifluoromethylation of Hydrazones Leading to the Formation of Quaternary α-Trifluoromethyl Diazenes.A. Prieto, D. Bouyssi and N. Monteiro. Asian J. Org. Chem. 2016; DOI: 10.1002/ajoc.201600160 (link)


C-H Difluoroalkylation of Aldehyde Hydrazones with Functionalized Difluoromethyl Bromides under Copper Catalysis. A. Prieto, R. Melot, D. Bouyssi, N. Monteiro. ACS Catalysis 20166, 1093


“Grignard reagents and Nickel” F. Fache, B. Pelotier, O. Piva in “Grignard Reagents and Transition Metal catalysts”; Ed J. Cossy, De Gruyter Ed., 2016, pp.61-113.(link)


Palladium-Catalyzed C(sp2) -H Alkylation of Aldehyde-Derived Hydrazones with Functionalized Difluoromethyl Bromides. A. Prieto, R. Melot, D. Bouyssi, N. Monteiro. Angew. Chem. Int. Ed. 201655, 1885.


Electrophilic Trifluoromethylation of Carbonyl Compounds and their Nitrogen Derivatives under Copper Catalysis. A. Prieto, O. Baudoin, D. Bouyssi, N. Monteiro, Chem. Commun., 2016, 52, 869.


Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent. E. Ismalaj, D. Le Bars, T. Billard Angew. Chem. Int. Ed. 2016, 55, 4790-4793. (link)


Metal-Free Direct Nucleophilic Perfluoroalkylthiolation with Perfluoroalkanesulfenamides. Q. Glenadel, M. Bordy, S. Alazet, A. Tlili, T. Billard Asian J. Org. Chem. 2016, 5, 428-433. (link)


First and second generation of trifluoromethanesulfenamide reagent: A trifluoromethylthiolating comparison. Q. Glenadel, S. Alazet, T. Billard J. Fluorine Chem. 2015, 179, 89-95. (link)


Direct [11C]Methylation of Amines from [11C]CO2 for the Synthesis of PET Radiotracers. F. Liger, T. Eijsbouts, F. Cadarossanesaib, C. Tourvieille, D. Le Bars, T. Billard Eur. J. Org. Chem. 2015, 6434-6438. (link)


Mild and Soft Catalyzed Trifluoromethylthiolation of Boronic Acids: The Crucial Role of Water. Q. Glenadel, S. Alazet, A. Tlili, T. Billard Chem. Eur. J. 2015, 21, 14694-14698. (link)


TEMPO-Catalyzed Oxidative Amidation of Alcohols via Hexafluoroisopropyl Esters. J.-M. Vatèle Synlett 2015, 2280-2284.


Acid-Catalyzed Synthesis of α-Trifluoromethylthiolated Carbonyl Compounds. Alazet, S.; Ismalaj, E.; Glenadel, Q.; Le Bars, D.; Billard, T. Eur. J. Org. Chem. 2015, 4607-4610. (link)


Le fluor en chimie organique : une montée en puissance (Fluorine in organic chemistry: gaining momentum). T. Billard, E. Magnier, J.-P. Vors Actualité Chimique 2015, 393-394, 56-61. (link)


Selective trifluoromethylthiolation of heteroaromatic sp2 C–H bonds with the 2nd generation of trifluoromethanesulfenamide reagent. S. Alazet, L. Zimmer, T. Billard J. Fluorine Chem. 2015, 171, 78-81. (link)


Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging. G. Becker, J. Colomb, V. Sgambato-Faure, L. Tremblay, T. Billard, L. Zimmer Eur. J. Nucl. Med. Mol. Imaging 2015, 42, 495-502. (link)


Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide. Alazet, S.; Billard, T. Synlett 2015, 26, 76-78. (link)


Total synthesis of (+)-Guaymasol. S. Feuillastre, O. Piva Synlett 2014, 2883-2886. (link)


TEMPO/NBu4Br-Catalyzed Selective Alcohol Oxidation with Periodic Acid. Mariam Attoui, Jean-Michel Vatèle Synlett 2014, 2923-2927. (link)


Binding of the PET radiotracer [18F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice. E. Levigoureux, S. Lancelot, C. Bouillot, F. Chauveau, M. Verdurand, J. Verchere, T. Billard, T. Baron, L. Zimmer Curr. Alzheimer Res. 2014, 11, 955-960. (link)


(Re)Investigation of the reactivity of uranium hexafluoride toward several organic functions at room temperature. O. Roy, B. Marquet, J.-P. Alric, A. Jourdan, B. Morel, B. R. Langlois, T. Billard J. Fluorine Chem. 2014, 167, 74-78. (link)


A Postmortem Study to Compare Agonist and Antagonist 5-HT1A Receptor-binding Sites in Alzheimer's Disease. G. Becker, N. Streichenberger, T. Billard, A. Newman-Tancredi, L. Zimmer CNS Neurosci. Ther. 2014, 20, 930-934. (link)


Multigram Laboratory Scale Synthesis of α-Trifluoromethoxy Carbonyl Compounds. Barbion, J.; Pazenok, S.; Vors, J.-P.; Langlois, B. R.; Billard, T. Org. Process Res. Dev. 2014, 18, 1037-1040. (link)


One-pot oxidative conversion of alcohols into nitriles by using a TEMPO/PhI(OAc)2/NH4OAc system. J.-M. Vatèle. Synlett 2014, 25, 1275-1278. (link)


Electrophilic Trifluoromethylthiolation of Carbonyl Compounds. Alazet, S.; Zimmer, L.; Billard, T. Chem. Eur. J. 2014, 20, 8589-8593. (link)


Molecular imaging of the serotonin 5-HT7 receptors: from autoradiography to positron emission tomography. Zimmer, L.; Billard, T. Rev. Neurosci. 2014, 25, 357-365. (link)


Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5-HT6 Serotoninergic Receptors. Colomb, J.; Becker, G.; Fieux, S.; Zimmer, L.; Billard, T. J. Med. Chem. 2014, 57, 3884-3890. (link)


Synthesis of seven-membered ring ethers and lactones. Piva, O. in "Topics in Heterocyclic Chemistry II » - Vol. 35. Maes, BUW; Cossy, J.; Polanc, S. Eds.; Springer: Heidelberg, 2014, p. 283-321.


Application of Prins Cyclization to the total synthesis of (+)-decytospolides A and B. Clarisse, D.; Fache, F. Tetrahedron Lett. 2014, 55, 2221-2222. (link)


Direct Trifluoromethylthiolation Reactions: The “Renaissance” of an Old Concept. F. Toulgoat, S. Alazet, T. Billard Eur. J. Org. Chem. 2014, 2415-2428. (link).


Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging. Colomb, J.; Becker, G.; Forcellini, E.; Meyer, S.; Buisson, L.; Zimmer, L.; Billard, T. Nucl. Med. Biol. 2014, 41, 330-337. (link)


Stereoselective Access to Trisubstituted Cyclopentanols from Chiral Unsaturated Oxo Esters by Ketyl Radical Cyclization. S. Feuillastre, B. Pelotier, O. Piva Eur. J. Org. Chem. 2014, 1753-1759. (link)


Regioselective Oxidative Cleavage of Benzylidene Acetals of Glycopyranosides with Periodic Acid Catalyzed by Tetrabutylammonium Bromide. Jean-Michel Vatèle Synlett 2014, 25, 115-119. (link)


PET Radiotracers for Molecular Imaging of Serotonin 5-HT1A Receptors. Billard, T.; Le Bars, D.; Zimmer, L. Curr. Med. Chem. 2014, 21, 70-81. (link)


Direct electrophilic N-trifluoromethylthiolation of amines with trifluoromethanesulfenamide. Alazet, S.; Ollivier, K.; Billard, T. Beilstein J. Org. Chem. 2013, 9, 2354-2357. (link)


Sequential oxidation-Prins reaction processes induced by the same iron salt : Direct access to 2-aryl-4-chloro-tetrahydropyrans from benzyl alcohols. F. Fache, M. Muselli, O. Piva. Synlett 2013, 24, 1781-1784. (link)


Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes. Alazet, S.; Zimmer, L.; Billard, T. Angew. Chem. Int. Ed. 2013, 52, 10814-10817. (link)


Merging cross-metathesis and radical cyclization : A straightforward access to 4-substituted benzosultams. S. Feuillastre, B. Pelotier, O. Piva. Synthesis 2013, 45, 810-816. (link)


Solvent-free, metal-free, Aza-Prins cyclization : Unprecedented access to δ-sultams. D. Clarisse, B. Pelotier, F. Fache. Chem. Eur. J. 2013, 19, 857-860. (link)


Synthesis of trifluoromethylated 1,5-benzoheteroazepines. Carole Christophe, Bernard R. Langlois, Thierry Billard. J. Fluorine Chem. 2013, 155, 118 – 123. (link)


Formation of C-SCF3 Bonds through Direct Trifluoromethylthiolation. Anis Tlili and Thierry Billard. Angew. Chem. Int. Ed. 2013, 52, 6818 – 6819. (link)


Unusual reactivities of acridine derivatives in catalytic hydrogenation. A combined experimental and theoretical study. Mignon, P.; Tiano, M.; Belmont, P.; Favre-Réguillon, A.; Chermette, H.; Fache, F. J. Mol. Catal. A: Chemical, 2013, 371, 63-69. (link)


Synthetic Studies on the Nhatrangins: Stereoselective Access to an Advanced Aldehyde Intermediate. Ludovic Raffier and Olivier Piva. Eur. J. Org. Chem. 2013, 1124–1131. (link)


Palladium-catalyzed desulfitative arylation of 3-haloquinolines with arylsulfinates. Julie Colomb, Thierry Billard. Tetrahedron Letters 2013, 54, 1471–1474. (link)


Asymmetric synthesis of andavadoic acid via base-catalyzed 5-exo-tet cyclization of a β-hydroperoxy epoxide. Bogdan Barnych, Bernard Fenet, Jean-Michel Vatèle. Tetrahedron, 2013, 69, 334-340. (link)


Acetogenin (Polypropionate) Derived Auxillaries: Hydroxyacids. O. Piva. In: Carreira E.M. and Yamamoto H. (eds.) Comprehensive Chirality, 2012, Amsterdam: Elsevier, Volume 3, pp. 202-213.


Acetogenin (Polypropionate) Derived Auxillaries: Hydroxyacid Derivatives. O. Piva. In: Carreira E.M. and Yamamoto H. (eds.) Comprehensive Chirality, 2012, Amsterdam: Elsevier, Volume 3, pp. 214-222.


Merging metathesis and organic, organocatalysis with photochemistry. O. Piva. European Photochemistry Newsletter, Dec. 2012, 62-64


Plakortolide Stereochemistry Revisited: The Checkered History of Plakortolides E and I. Ken W. L. Yong, Bogdan Barnych, James J. De Voss, Jean-Michel Vatèle, and Mary J. Garson. J. Nat. Prod. 2012, 75, 1792−1797.


Electrophilic Trifluoromethanesulfanylation of Organometallic Species with Trifluoromethane-sulfanamides. Baert, F.; Colomb, J.; Billard, T. Angew. Chem. Int. Ed. 2012, 51, 10382-10385. (link)


Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles. Damien Clarisse, Bernard Fenet, Fabienne Fache. Org. Biomol. Chem. 2012, 10, 6587-6594.


Application of a Cross-Metathesis and Intramolecular Aza-Diels–Alder Sequence to the Synthesis of trans-2,3-Disubstituted Tetrahydroquinolines. Sophie Feuillastre, Vincent Pellet, Olivier Piva. Synthesis 2012, 2431-2435.


Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis. Loc Tomas, Gustav Boije af Gennäs, Marie Aude Hiebel, Peter Hampson, David Gueyrard, Béatrice Pelotier, Jari Yli-Kauhaluoma, Olivier Piva, Janet M. Lord, Peter G. Goekjian. Chem. Eur. J. 2012, 18, 7452 – 7466.


Radiosynthesis and Preclinical Evaluation of 18F-F13714 as a Fluorinated 5-HT1A Receptor Agonist Radioligand for PET Neuroimaging. Laëtitia Lemoine, Guillaume Becker, Bernard Vacher, Thierry Billard, Sophie Lancelot, Adrian Newman-Tancredi, and Luc Zimmer. J. Nucl. Med. 2012, 53, 969-976. (link)


Exploratory studies toward the synthesis of the peroxylactone unit of plakortolides. Bogdan Barnych, Jean-Michel Vatèle. Tetrahedron, 2012, 68, 3717-3724.


Electrophilic trifluoromethanesulfanylation of indole derivatives. Aurélien Ferry, Thierry Billard, Eric Bacqué, Bernard R. Langlois. J. Fluorine Chem., 2012, 134, 160-163. (link)


Total Synthesis of seco-Plakortolide E and (−)-ent-Plakortolide I: Absolute Configurational Revision of Natural Plakortolide I. Bogdan Barnych, Jean-Michel Vatèle. Org. Lett., 2012, 14, 564–567.


Easy access to 2-alkyl and 2-arylthiazolines using microwave irradiation and heteropolyacid catalysis. F. Fache, F. Cros, O. Piva, F. Lefebvre. Synth. Commun 2012, 42, 2098-2109.


Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions. Damien Clarisse, Béatrice Pelotier, Olivier Piva and Fabienne Fache. Chem. Commun. 2012, 48, 157-159.


Desymmetrization of Hepta-1,6-dien-4-ol by Prins Reaction and Subsequent. Cross-Metathesis: Access to Diospongine A Homologues. L. Raffier, F. Izquierdo, O. Piva. Synthesis, 2011, 4037-4044.


Comparison of 4 Radiolabeled Antagonists for Serotonin 5-HT7 Receptor Neuroimaging: Toward the First PET Radiotracer. Laetitia Lemoine, Julien Andries, Didier Le Bars, Thierry Billard, Luc Zimmer. J. Nucl. Med. 2011, 52, 1811-1818. (link)


La métathèse: une ronde d'atomes. O. Piva. Pour la Science Dossier N°73: Les Océans et la chimie durable. Oct.-Déc. 2011, 64-68.


Towards the Synthesis of 4,19-diol Derivative of (-)-Mycothiazole: Synthesis of a Potential Key Intermediate. F. Batt, F. Fache. Eur. J. Org. Chem. 2011, 6039-6055.


(1S,2R,4R)-2-allyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol. L. Raffier, O. Piva. Electronic encyclopedia of reagents for organic synthesis - Wiley 2011.


One-Pot Bi(OTf)3-Catalyzed Oxidative Deprotection of tert-Butyldimethyl Silyl Ethers with TEMPO and Co-Oxidants . Bogdan Barnych, Jean-Michel Vatèle. Synlett 2011, 2048-2052.


1,4-Additions of electron-rich heterocycles onto β-perfluoroalkyl enones. Julia Leuger, Gaelle Blond, Thierry Billard, Günter Haufe, Bernard R. Langlois. J. Fluorine Chem. 2011, 132, 799-803. (link)


Synthetic Studies toward the Bicyclic Peroxylactone Core of Plakortolides. Bogdan Barnych, Jean-Michel Vatèle. Synlett 2011, 1912-1916.


Synthesis and Biological Evaluation of Potential 5-HT7 Receptor PET Radiotracers. Julien Andriès, Laetitia Lemoine, Didier Le Bars, Luc Zimmer, Thierry Billard. Eur. J. Med. Chem. 2011, 46, 3455-2461. (link)


Application of the diastereoselective photodeconjugation of α,β-unsaturated esters to the synthesis of Gymnastatin. H. L. Raffier, O. Piva. Beilstein J. Org. Chem. 2011, 7, 151–155.


Synthesis of 6-(1,2,3-triazoloalkyl)-a-pyrones by a cascade RCM/CM and click chemistry sequence. F. Cros, J. Ruiz, B. Pelotier, O. Piva .Synlett 2010, 2621-2624


Bromotrichloromethane. F. Cros. Synlett 2010, 2204-2205


Stereoselective synthesis of the C1-C13 fragment of bistramide A. M. A. Hiebel, B. Pelotier, O. Piva. Tetrahedron Lett. 2010, 51, 5091-5093.


Synthesis of β-Trifluoromethylated Δ1-Pyrrolines. Olivier Marrec, Carole Christophe, Thierry Billard, Bernard Langlois, Jean-Pierre Vors, Sergii Pazenok. Adv. Synth. Catal. 2010, 352, 2825 – 2830. (link)


A New and Direct Trifluoromethoxylation of Aliphatic Substrates with 2,4-Dinitro(trifluoromethoxy)benzene. Olivier Marrec, Thierry Billard, Jean-Pierre Vors, Sergii Pazenok, Bernard R. Langlois. Adv. Synth. Catal. 2010, 352, 2831 – 2837. (link)


Lewis acid-catalyzed oxidative rearrangement of tertiary allylic alcohols mediated by TEMPO. J.-M. Vatèle. Tetrahedron 2010, 66, 904-912.


Looking for a 5-HT7 radiotracer for positron emission tomography. Julien Andriès, Laëtitia Lemoine, Alice Mouchel-Blaisot, Sandrine Tang, Mathieu Verdurand, Didier Le Bars, Luc Zimmer, Thierry Billard. Bioorg. Med. Chem. Lett. 2010, 20, 3730-3733. (link)


Regioselective Tandem Ring-Closing/Cross-Metathesis of 1,5-hexadien-3-ol derivatives: Application to a Total Synthesis of Rugulactone F. Cros, B. Pelotier, O. Piva Eur. J. Org. Chem. 2010, 5063-5070.


Stereocontrolled Synthesis of a Highly Functionalized Core Structure of the Aurisides by Ring-Closing Metathesis E. Bourcet, F. Fache, O. Piva Eur. J. Org. Chem. 2010, 4075-4087 .


Vers une chimie moléculaire verte. J. M. Campagne, F. Agbossou, T. Ayad, O. Baudoin, G. Buono, I. Chataignier, C. Crévisy, I. Dez, M. Donnard, F. Fache, C. Feasson, A-C. Gaumont, L. Giordano, P. Heseman, F. Marsais, M. Mauduit, V. Michelet, A. Mortreux, P. Phansavath, O. Piva, J.P. Roblin, J. Rouden, M. Taillefer, P. Y. Toullec, T. Tschmaber, V. Vidal Actualité Chimique 2010, 338-339, 14-27.


Synthesis of the core structure of the aurisides. E. Bourcet, F. Fache, O. Piva Tetrahedron 2010, 66, 1319-1326.


Microwave-assisted cross-metathesis of unsaturated thiocyanates: Application to the synthesis of thiocyanatins A and B and analogues. F. Cros, B. Pelotier, O. Piva Synthesis 2010, 233-238.


A deeper insight into direct trifluoromethoxylation with trifluoromethyl triflate. Olivier Marrec, Thierry Billard, Jean-Pierre Vors, Sergii Pazenok, Bernard R. Langlois. J. Fluorine Chem. 2010, 131, 200-207. (link)