Michele FIORE


Dr Michele FIORE (MCF)

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04 72 44 80 80

2019 - Present : Associate Professor (MCF HDR), Université Claude Bernard Lyon 1
: Habilitation à Diriger les Recherches (HDR), Université Claude Bernard Lyon 1
2014 - 2019
: Assistant Professor (MCF), Université Claude Bernard Lyon 1
2011 - 2014 : Postdoctoral studies, Université Grenoble Alpes (Prof Olivier Renaudet)
2009 - 2011 : Junior Scientist, Sienabiotech Spa (Italy)
2008 - 2009 : Postdoctoral studies, University of Ferrara (Prof Alessandro Dondoni / Prof Alberto Marra)
2003 - 2007 : PhD in Agrobiology and Agrochemistry, University of Naples (Prof. Antonio Evidente)

Editorial contribution:


Guest Editor for the Special Issue of LIFE (ISSN 2075-1729): “The Origin and Early Evolution of Life: Prebiotic Chemistry” http://www.mdpi.com/journal/life/special_issues/Prebiotic_Chemistry


Member of the Editorial Board of Journal of Systems Biology & Proteome Research


Incoming publications


Phospholipids: nature, preparation and use. From organic synthesis, evolutionary to modern synthesis.

Michele Fiore* and René Buchet, Chem. Rev., 2018, Synopsis accepted.



37. Investigating prebiotic protocells for a comprehensive understanding of the origins of life: a prebiotic systems chemistry perspective.

A. Lopez & M. Fiore* Life, 2019, 9, 49; doi:10.3390/life9020049


36. Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside

D. Fayolle, B. Doumèche, N. Berthet, O. Renaudet, P. Strazewski, M. Fiore*

Beilstein J. Org. Chem. 2019, 15, 937–946. doi:10.3762/bjoc.15.90


35. Identification of a new natural gastric lipase inhibitor from star anise

J. Kamoun, R. Rahiern, M. Sellami, I. Koubaa, P. Mansuelle, R. Lebrun, A. Berlioz-Barbier, M. Fiore, K. Alvarez, A. Abousalham, F. Carrière, A. Aloulou, Food Funct, 2019, 10, 469-478


34. The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature,

preparation and use, including synthesis under plausible prebiotic conditions. 

M. Fiore*, Org. Biomol. Chem., 2018, 16, 3068–3086


33. Rapid purification of giant lipid vesicles by microfiltration. 

D. Fayolle, M. Fiore, P. Stano and P.Strazewski; 

PLoS ONE, 2018, 13: e0192975, DOI:10.1371/journal.pone.0192975 


32. Glass Microsphere-Supported Giant Vesicles as Tools for Observation of Self-reproduction of Lipid Boundaries; M. Fiore*, O. Maniti, A. Girard-Egrot, P-A Monnard and P. Strazewski* 

Angew. Chem. Int. Ed., 2018, 57, 282–286; 


31. Crude phosphorylation mixitures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments; D. Fayolle, E. Altamura, A. D’Onofrio, W. J. Madanamothoo, B. Fenet, F. Mavelli, R. Buchet, P. Stano*, M. Fiore* and P.Strazewski* Sci. Rep., 2017, 7, 18106; 


30. Giant vesicles from rehydrated crude phosphorylation mixitures containing mono-alkyl phosphoethanolamine and its analogues;

M. Fiore*, W. Madanamoothoo, A. Berlioz-Barbier, O. Manniti, A. Girard-Egrot, R. Buchet, P. Strazewski*; Org. Biomol. Chem., 2017, 15, 4231–4238 


29. Bringing down to earth prebiotic nucleosides and nucleotides  

M. Fiore, P. Strazewski*; Angew. Chem. Int. Ed., 2016, 55, 13930–13933 


28. Prebiotic lipidicamphiphiles and condensing agents on the early Earth 

M. Fiore*, P. Strazewski* Life, 2016, 6, 17.


27. Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells. 

S. Fallarini, A. Brittoli, M. Fiore, G. Lombardi, O. Renaudet, B. Richichi, C. Nativi, 

Glycoconj. J., 2017, 34, 553–562


26. Chemo-bacterial synthesis of a sialyl-Tncyclopeptide vaccine Candidate. 

E. Richard, C. Pifferi, M. Fiore, E. Samain, A. Le Gouëllec, S. Fort, O. Renaudet, B. Priem,

ChemBioChem., 2017,18, 1730–1734


25. Aminooxiylated Carbohydrates: Synthesis and Applications. 

C. Pifferi, G. C. Daskhan, M. Fiore, T. C. Shiao, R. Roy, O. Renaudet, 

Chem. Rev. 2017, 117, 9839−9873


24. Role of a preorganized scaffold presenting four residues of a GM3 lactone mimetic on melanoma progression

B. Richichi, G. Comito, O. Renaudet, M. Fiore, A. Marra, B. Stecca, L. Pasquato, P. Chiarugi, C. Nativi 

ACS Med. Chem. Lett.2016, 7, 28–33


23. Divergent and convergent synthesis of GalNAc-conjugated dendrimers using dual orthogonal ligations 

B. Thomas, C. Pifferi, G. C. Daskhan,M. Fiore, N. Berthet, O. Renaudet

Org. Biomol. Chem., 2015, 13, 11529–11538.


22. Multivalent glycocyclopeptides: toward nano-sized glycostructures

G. C. Daskhan, N. Berthet, B. Thomas, M. Fiore, O. Renaudet

Carbohyd. Res., 2015, 405, 13–22.


21. Oligomersfor molecular recognition made by AROP of disubstituted cyclopropane-1,1-dicarboxiylates

S. Peyrat, M. Fiore, N. Illy, S. Boileau, V. Wintgens, N. Berthet, O. Renaudet, J. Penelle, V. Barbier, 

Proceeding MACRO 2014: Recent development in polymer synthesis, 284–286.


20. Clustered Tn-Antigen Mimetics-Based Cancer Therapeutic Vaccine Induces Strong Antibody-Mediated Protective Immunity

B. Richichi, B. Thomas, M. Fiore, R. Bosco, K. Kabbara, K. Cao, H. Qureshi, C. Nativi, O. Renaudet, L. Ben Mohamed,  Angew. Chem. Int. Ed., 2014, 53, 11917–11920.


19. A multi-ligation strategy for the synthesis of hetero functionalized glycosylated scaffolds

B. Thomas, M. Fiore, G. C. Daskhan, N. Spinelli, O. Renaudet

Chem. Commun. 2014, 50, 8989–8992.


18. New glycopolimers as multivalent system for lectin recognition 

M. Fiore, N. Berthet, O. Renaudet, V. Barbier

MedChem Comm., 2014, 5, 1202–1207.


17. Orthogonal dual thiol-chloroacetyl and thiol-ene couplings for the sequential one-pot assembly of heteroglycoclusters

M.Fiore, G. C.Daskhan, B. Thomas, O. Renaudet

Beilstein J. Org. Chem., 2014, 10, 1557–1563.


16. Access to topological biomolecular platform using a simple protocol based on oxime ligation

K. Křenek, R. Gazak, M. Sulc, G. C. Daskhan, J. Garcia, M. Fiore, P. Dumy, V. Křen, O. Renaudet

Carbohyd. Res., 2014, 393, 9–14


15. Reevaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides. 

D. Rozbeský, J. Krejzová, K. Křenek, J. Prchal, R. Hrabal, M. Kozísek, L. Weignerová, M. Fiore, P. Dumy, O. Renaudet, V. Křen

Int. J. Mol. Sci., 2014, 14, 1271–1283


14. Tetravalent GlcNAcGlycoclusters: influence of the Linker for the Weat Germ Agglutinin Interaction. 

M. Fiore, N. Berthet, P. Dumy, A. Marra, A. Dondoni, E. Gillion, A. Imberty, O. Renaudet 

Org. Biomol. Chem., 2013, 11, 7113–7122


13. Facile Synthesis of multi-antigenic platform as vaccine candidates against cancers                  

M. Fiore, B. Thomas, V. Dulery, P. Dumy, O. Renaudet

New.  J. Chem., 2013, 37, 286–289


12. Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations

B. Thomas, M. Fiore, I. Bossu, P. Dumy, O. Renaudet

BeilsteinJ. Org. Chem., 2012, 8, 421–427


I.9.2.3. Articles écrits pendant le stage postdoctoral au sein du laboratoire de chimie à Ferrare (Equipe Prof. Alessandro Dondoni)

11. Synthesis of S-glycosyl amino acids and S-glycosilpeptides via photoinduced click thiol-ene coupling

M. Fiore, S. Pacifico, M. Lo Conte, A. Marra, A. Dondoni

Tetrahedron Lett., 2011,  52 , 444–447


10. Photoinduced Thiol Ene Coupling as a Click Ligation tool for Thiodisaccarides Synthesis

M. Fiore, A. Marra, A. Dondoni

J. Org. Chem., 2009, 74, 4422–4425


09. Single and Dual glycoside clustering around calix[4]arene scaffolds via click thiol ene and azide-alkyne cycloaddition

M. Fiore, A. Chambery, A. Marra, A. Dondoni

Org. Biomol. Chem., 2009, 7, 3910–3913

08. Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata

Stephen O. Duke, Antonio Evidente, Michele Fiore, Agnes M. Rimando, Franck E. Dayan, Maurizio Vurro, Nicole Christiansen, Ralf Looser, Johannes Hutzler, Klaus Grossmann

Pest. Biochem. Physiol., 2011, 100, 41–50


07. Analysis of phytotoxic fungal toxins from Ascochyta caulina liquid culture

Agnes M, Rimando, MicheleFiore, Antonio Evidente

Abstr. Pap. Am. Chem. S., 2010, 239, 96–99


06. A new GC-MS method for the analysis of ascaulitoxin, its aglycone and 4-aminoproline from culture filtrates of Ascochita caulina

Michele Fiore, Agnes Rimando, Anna Andolfi, Antonio Evidente

Anal. Methods, 2010, 2, 159–163 


05. Diplofuranones A and B, two Further New 4-Monosubstituted 2(3H)-dihydrofuranones Produced by Diplodi acorticola, a Fungus Pathogen of Cork Oak

Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Antonio Franceschini, Lucia Maddau

Archiv. O. C., 2007, 7, 318–320


04. Diplobifuranylones A and B, 5’-Monosubstituted Tetrahydro-2H-bifuranyl-5-ones Produced by Diplodia corticola, a Fungus Pathogen of Cork Oak

Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Lucia Maddau, Antonio Franceschini, Francesco Marras, Andrea Motta

J. Nat. Prod., 2006, 69, 671–674


03. Chemical and biological characterisation of sapinopyridione, a phytotoxic 3,3,6-trisubstituted-2,4-pyridione produced by Sphaeropsis sapinea, a toxigenic pathogen of native and exiotic conifers, and its derivatives

Antonio Evidente, Michele Fiore, Giovanni Bruno,Lorenzo Sparapano, Andrea Motta 

Phytochemistry, 2006, 67, 1019–1028


02. Occurence, isolation and biological activity of phytotoxic metabolites produced in vitro by Spaeropsis sapinea, pathogenic fungus of Pinus radiata

Annalisa Cabras, Maria A. Mannoni, Salvatorica Serra, Anna Andolfi, Michele Fiore, Antonio Evidente

Eur. J. Plant Path., 2006, 115, 187–193


01. Stimulation of Orobanche ramosa seed germination by fusicoccin derivatives: A structure–activity relationship study

Antonio Evidente, Anna Andolfi, Michele Fiore, Angela Boari, Maurizio Vurro 

Phytochemistry, 2006, 67, 19–26